HDL and Atherosclerosis

HDL, Atherosclerosis, and Emerging Therapies

This review aims to provide an overview on the properties of high-density lipoproteins (HDLs) and their cardioprotective effects. Emergent HDL therapies will be presented in the context of the current understanding of HDL function, metabolism, and protective antiatherosclerotic properties. The epidemiological association between levels of HDL-C or its major apolipoprotein (apoA-I) is strong, gr...

1 HDL , Lipid Peroxidation , and Atherosclerosis

HDL cholesterol and protective factors in atherosclerosis.

A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C levels are linked to rates of coronary events. The cardioprotective effects of HDL-C have been attributed to its role in reverse cholesterol transport, its effects on endothelial cells, and its antioxidant activity. ...

The role of dysfunctional HDL in atherosclerosis.

This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be imp...

Genetics of increased HDL cholesterol levels: insights into the relationship between HDL metabolism and atherosclerosis.

Astrong inverse association exists between plasma HDL cholesterol (HDL-C) levels and incidence of coronary artery disease.1 Although environmental factors play a role, variation in HDL-C levels are at least 50% genetically determined.2 The genetics of syndromes of very low HDL-C have been extensively studied. Mutations in apoA-I (the major HDL structural protein), ABCA1 (which promotes efflux o...